Article

LDB1-dependent enhancer connectivity defines T-cell leukemia identities and masks metabolic vulnerabilities

2026-06-30

Abstract excerpt

Spatial enhancer connectivity is fundamental to proper gene regulation. Enhancer dysregulation has emerged as a hallmark of cancers, including T-cell acute lymphoblastic leukemias (T-ALL). T-ALL are aggressive malignancies characterized by marked transcriptional heterogeneity driven by distinct stages of developmental arrest and diverse noncoding alterations. How these cancers co-opt nuclear architecture to rewire...

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Literature Corpus work: 1a9f5f9b-4b34-5ff0-8067-cdb980a14e45
DOI: 10.64898/2026.06.29.733236

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