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Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression in patients

29 Jul 2025

Abstract excerpt

ABSTRACT: Genetic alterations alone cannot account for the diverse phenotypes of cancer cells. Even cancers with the same driver mutation show significant transcriptional heterogeneity and varied responses to therapy. However, the mechanisms underpinning this heterogeneity remain underexplored. Here, we find that novel enhancer usage is a common feature in acute lymphoblastic leukemia (ALL). In particular,...

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PMID: 40729681
DOI: 10.1182/blood.2024028019

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