Automated CUT&Tag profiling of chromatin heterogeneity in mixed-lineage leukemia

Abstract excerpt

Acute myeloid and lymphoid leukemias often harbor chromosomal translocations involving the Mixed Lineage Leukemia-1 gene, encoding the KMT2A lysine methyltransferase. The most common translocations produce in-frame fusions of KMT2A to other chromatin regulatory proteins. Here we develop a strategy to map the genome-wide occupancy of oncogenic KMT2A fusion proteins in primary patient samples regardless of fusion p...

Topics

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• Acute Myeloid Leukemia Research
• Adenylyl Cyclases
• Epigenetics and DNA Methylation
• Genomics and Chromatin Dynamics
• Histone Deacetylase Inhibitors Research
• Histone-Lysine N-Methyltransferase
• Myeloid-Lymphoid Leukemia Protein
• Protein Degradation and Inhibitors

Identifiers and source

Literature Corpus work

30455b40-df7b-5c44-a705-2fe38ea26e0a

DOI

10.1101/2020.10.06.328948