A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia

Abstract excerpt

<h4>Summary</h4> A small set of lineage-restricted transcription factors (TFs), termed core regulatory circuitry (CRC), control cell identity and malignant transformation. Here, we integrated gene dependency, chromatin architecture and TF perturbation datasets to characterize 31 core TFs in acute myeloid leukemia (AML). Contrary to a widely accepted model, we detected a modular CRC structure with hierarchically o...

Topics

Open a Topic to create a Post that cites this publication.

• Chromatin Assembly and Disassembly
• Enhancer Elements, Genetic
• fms-Like Tyrosine Kinase 3
• Gene Expression Regulation, Leukemic
• Gene Regulatory Networks
• Nucleophosmin
• Principal Component Analysis
• Protein Processing, Post-Translational

Identifiers and source

Literature Corpus work

33833dfa-8c9d-55a5-984c-662a5acc9be3

DOI

10.1101/2021.08.03.454902