Article

GluProRS Inhibition Abolishes Cancer Stem Cells in Pancreatic Cancer by Inducing the Integrated Stress Response and Countering TGFβ/Activin-SMAD2/3-HIF1A

2025-05-19

Abstract excerpt

<title>Abstract</title> <p>The developmentally dynamic stem cell-like subpopulation in cancers known as cancer stem cells (CSCs) metastasize efficiently, form new tumours, and are resistant to current therapeutics. Understanding the molecular mechanisms of the stem cell-like state could help eliminate CSCs via novel therapeutic applications in aggressive cancers such as pancreatic ductal adenocarcinoma (PDAC). He...

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Literature Corpus work: 3faf0f4b-f9b1-5eeb-a008-58e31e576c46
DOI: 10.21203/rs.3.rs-6672561/v1

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