Article

Quantitative secretomics identifies ligand-receptor pairs in pancreatic cancer that mediate bidirectional crosstalk between cancer stem cells and nociceptors

2024-02-29

Abstract excerpt

<title>Abstract</title> <p>Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest and most metastatic cancers in human. PDACs respond poorly to therapies, partly due to cancer stem cells (CSCs) that self-renew, survive chemotherapies, metastasise and replenish the tumour. Factors secreted by tumour cells mediate autocrine/paracrine crosstalk with surroundingcells contributing to the stem cell niche but a...

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Literature Corpus work: 61ee78ea-43a7-5ccc-a956-fe2c6f7a6844
DOI: 10.21203/rs.3.rs-3994602/v1

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