Article

BAZ2A-SUV39H1-SMAD2/3-OCT4 regulates stemness, cell cycle exit and chemoresistance in pancreatic ductal adenocarcinoma

2023-11-14

Abstract excerpt

<title>Abstract</title> <p>Tumorigenesis leads to the dedifferentiation of some cancer cells partly resemble stem cells. The maintenance circuitries and epigenetic regulatory complexes that regulate this stem cell-like state known as cancer stem cells (CSCs) are largely unclear. Here we aimed to find strategies for eliminating CSCs in pancreatic cancer (PDAC), one of the most metastatic and lethal cancers in huma...

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Literature Corpus work: 201d4529-3f79-51d5-af41-5ed0b8a204d7
DOI: 10.21203/rs.3.rs-3570401/v1

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