Article

Ras-dependent activation of BMAL2 regulates hypoxic metabolism in pancreatic cancer

2023-03-21

Abstract excerpt

<h4>Summary</h4> KRAS is the archetypal oncogenic driver of pancreatic cancer. To identify new modulators of KRAS activity in human pancreatic ductal adenocarcinoma (PDAC), we performed regulatory network analysis on a large collection of expression profiles from laser capture microdissected samples of PDAC and benign controls. We discovered that BMAL2, a member of the PAS family of transcription factors, promote...

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Literature Corpus work: faab70cb-d9dc-5cf9-98a9-a1053f28611d
DOI: 10.1101/2023.03.19.533333

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