Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypoxia Promotes Pancreatic Cancer Cell Dedifferentiation to Stem-Like Cell Phenotypes With High Tumorigenic Potential by the HIF-1α/Notch Signaling Pathway.

Pancreas - 1 Jan 2000

Mu Rui, Zou Yong-Kang, Tu Kui, Wang Dian-Bei, Tang Dan, Yu Zhou, Zhao Lijin

Abstract excerpt

OBJECTIVES: This study aimed to investigate the effect and mechanism of hypoxia on pancreatic cancer (PC) cell dedifferentiation and tumorigenic potential. METHODS: Inhibition of hypoxia-inducible factor 1α (HIF-1α) and overexpression of Notch1 in PC HS766T cell lines were by lentiviral transfection. The expression of stem cell-specific markers C-X-C motif chemokine receptor 4, CD44, and Nestin was detected by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Dedifferentiation
Share to Cell Movement

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Mice, Nude

Share to Neoplasm Invasiveness

Share to Neoplastic Stem Cells

Share to Pancreatic Neoplasms

Share to Receptor, Notch1

Source

Identifiers

PMID: 34016895
DOI: 10.1097/MPA.0000000000001828

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypoxia Promotes Pancreatic Cancer Cell Dedifferentiation to Stem-Like Cell Phenotypes With High Tumorigenic Potential by the HIF-1α/Notch Signaling Pathway.PMID 34016895Read ↗

HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell propertiesSemantic proximity Read ↗

HNF1A is a Novel Oncogene and Central Regulator of Pancreatic Cancer Stem CellsSemantic proximity Read ↗

Concise Review: Stem Cells in Pancreatic Cancer: From Concept to TranslationSemantic proximity Read ↗

The Role of lncRNAs in the Stem Phenotype of Pancreatic Ductal Adenocarcinoma.Semantic proximity Read ↗

Pancreatic Cancer Stem-like Cells Display Aggressive Behavior Mediated via Activation of FoxQ1Semantic proximity Read ↗

Holoclone Forming Cells from Pancreatic Cancer Cells Enrich Tumor Initiating Cells and Represent a Novel Model for Study of Cancer Stem CellsSemantic proximity Read ↗

Functional Characterization of miR-216a-5p and miR-125a-5p on Pancreatic Cancer Stem CellsSemantic proximity Read ↗

Pancreatic tumor microenvironment confers highly malignant properties on pancreatic cancer cellsSemantic proximity Read ↗

Pancreatic Tumor Microenvironment Factor Promotes Cancer Stemness via SPP1-CD44 Axis.Semantic proximity Read ↗

Epithelial and Mesenchymal-like Pancreatic Cancer Cells Exhibit Different Stem Cell Phenotypes Associated with Different Metastatic PropensitiesSemantic proximity Read ↗

MiR-1181 inhibits stem cell-like phenotypes and suppresses SOX2 and STAT3 in human pancreatic cancer.Semantic proximity Read ↗

GluProRS Inhibition Abolishes Cancer Stem Cells in Pancreatic Cancer by Inducing the Integrated Stress Response and Countering TGFβ/Activin-SMAD2/3-HIF1ASemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.