Article

HNF1A is a Novel Oncogene and Central Regulator of Pancreatic Cancer Stem Cells

2017-12-22

Abstract excerpt

<h4>ABSTRACT</h4> The biological properties of pancreatic cancer stem cells (PCSCs) remain incompletely defined and the central regulators are unknown. By bioinformatic analysis of a PCSC-enriched gene signature, we identified the transcription factor HNF1A as a putative central regulator of PCSC function. Levels of HNF1A and its target genes were found to be elevated in PCSCs and tumorspheres, and depletion of H...

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Literature Corpus work: a9290a6b-d7f8-5da9-9794-e82845b375be
DOI: 10.1101/238097

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