Article

Stressed β-cells contribute to loss of peri-islet extracellular matrix in type 1 diabetes

2025-06-27

Abstract excerpt

Type 1 diabetes (T1D) is characterized by the immune-mediated destruction of insulin-producing β-cells in pancreatic islets. The peri-islet extracellular matrix (ECM) is a complex protein barrier that is lost in T1D, in part due to infiltrating immune cells. The contribution of stressed β-cells to ECM degradation during T1D remains unclear. To bridge this gap, we used 12–15-week-old NOD mice and pancreas sections...

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Literature Corpus work: 3f5770e7-6f3a-5f29-9371-d3a4a245edf5
DOI: 10.1101/2025.06.25.661601

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