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The Role of β Cell Stress and Neo-Epitopes in the Immunopathology of Type 1 Diabetes

18 Feb 2021

Abstract excerpt

Due to their secretory function, β cells are predisposed to higher levels of endoplasmic reticulum (ER) stress and greater sensitivity to inflammation than other cell types. These stresses elicit changes in β cells that alter their function and immunogenicity, including defective ribosomal initiation, post-translational modifications (PTMs) of endogenous β cell proteins, and alternative splicing. Multiple...

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PMID: 33679609
DOI: 10.3389/fendo.2020.624590

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