Article
Immune-mediated beta-cell destruction in vitro and in vivo-A pivotal role for galectin-3.
Biochemical and biophysical research communications - 26 May 2006
Karlsen Allan E, Størling Zenia M, Sparre Thomas, Larsen Martin R, Mahmood Amer, Størling Joachim, Roepstorff Peter, Wrzesinski Krzysztof, Larsen Peter Mose, Fey Stephen, Nielsen Karin, Heding Peter, Ricordi Camillo, Johannesen Jesper, Kristiansen Ole P, Christensen Ulla B, Kockum Ingrid, Luthman Holger, Nerup Jørn, Pociot Flemming
Abstract excerpt
Pro-apoptotic cytokines are toxic to the pancreatic beta-cells and have been associated with the pathogenesis of Type 1 diabetes (T1D). Proteome analysis of IL-1beta exposed isolated rat islets identified galectin-3 (gal-3) as the most up-regulated protein. Here analysis of human and rat islets and insulinoma cells confirmed IL-1beta regulated gal-3 expression of several gal-3 isoforms and a complex in vivo...
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