Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

2α-Methyl-19-nor-(20S)-1,25-dihydroxyvitamin D(3) protects the insulin 2 knockout non-obese diabetic mouse from developing type 1 diabetes without hypercalcaemia.

Clinical and experimental immunology - 1 Dec 2011

Kiekhaefer C M, Weber B, Huggins M, Gorichanaz C, Nehring J A, DeLuca H F

Abstract excerpt

Type 1 diabetes (T1D) is an autoimmune disease that destroys the insulin-producing beta-islet cells of the pancreas. Currently, there are no treatment modalities for prevention of T1D, and the mechanisms influencing disease inception and early progression are not well understood. We have used the insulin 2(-/-) non-obese diabetic (Ins2(-/-) NOD) model to study stages of T1D and to examine the protective effects...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcitriol
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD8-Positive T-Lymphocytes

Share to Glucose Tolerance Test

Share to Hypoglycemic Agents

Share to Insulin-Secreting Cells

Share to Islets of Langerhans

Share to Mice, Inbred NOD

Source

Open in PubMed Open full text

Identifiers

PMID: 22059989
DOI: 10.1111/j.1365-2249.2011.04481.x
PMCID: PMC3232379

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

2α-Methyl-19-nor-(20S)-1,25-dihydroxyvitamin D(3) protects the insulin 2 knockout non-obese diabetic mouse from developing type 1 diabetes without hypercalcaemia.PMID 22059989Read ↗

Advances in our understanding of the pathophysiology of Type 1 diabetes: lessons from the NOD mouse.Semantic proximity Read ↗

Nonobese diabetic mice express aspects of both type 1 and type 2 diabetes.Semantic proximity Read ↗

Genetic and Pharmacologic Models for Type 1 DiabetesSemantic proximity Read ↗

Molecular phenotyping of immune cells from young NOD mice reveals abnormal metabolic pathways in the early induction phase of autoimmune diabetes.Semantic proximity Read ↗

The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes.Semantic proximity Read ↗

Calorie Restriction Upregulates Islet PD-L1 Signaling and Decreases the Risk of Auto-immune Diabetes Onset in NOD MiceSemantic proximity Read ↗

A propensity to hyperinsulinaemia underpins diet-induced diabetes in NOD <sup> <i>k</i> </sup> miceSemantic proximity Read ↗

The protection of Gα <sub>z</sub> -null NOD mice from hyperglycemia is sexually dimorphic and only partially β-cell autonomousSemantic proximity Read ↗

Beta-cell Cre expression and reduced <i>Ins1</i> gene dosage protect mice from type 1 diabetesSemantic proximity Read ↗

Independent genetic regulation of T-cell and antigen-presenting cell participation in autoimmune islet inflammation.Semantic proximity Read ↗

Blockade of the programmed death-1 (PD1) pathway undermines potent genetic protection from type 1 diabetes.Semantic proximity Read ↗

Stressed β-cells contribute to loss of peri-islet extracellular matrix in type 1 diabetesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.