Article

Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis

2024-12-29

Abstract excerpt

<h4>Summary</h4> The loss of insulin secretory function associated with type 1 diabetes (T1D) is attributed to the immune-mediated destruction of beta cells. Yet, at onset of T1D, patients often have a significant beta cell mass remaining while T cell infiltration of pancreatic islets is sporadic. Thus, we investigated the hypothesis that the remaining beta cells in T1D are largely dysfunctional using live human...

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Literature Corpus work: 00aaf8da-1aae-53e4-a2da-7bd91a49f600
DOI: 10.1101/2024.12.29.630665

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