Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes.

doi:10.1038/ng.3531

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Article

Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes.

Nature genetics - 1 May 2016

Dooley James, Tian Lei, Schonefeldt Susann, Delghingaro-Augusto Viviane, Garcia-Perez Josselyn E, Pasciuto Emanuela, Di Marino Daniele, Carr Edward J, Oskolkov Nikolay, Lyssenko Valeriya, Franckaert Dean, Lagou Vasiliki, Overbergh Lut, Vandenbussche Jonathan, Allemeersch Joke, Chabot-Roy Genevieve, Dahlstrom Jane E, Laybutt D Ross, Petrovsky Nikolai, Socha Luis, Gevaert Kris, Jetten Anton M, Lambrechts Diether, Linterman Michelle A, Goodnow Chris C, Nolan Christopher J, Lesage Sylvie, Schlenner Susan M, Liston Adrian

Abstract excerpt

Type 1 (T1D) and type 2 (T2D) diabetes share pathophysiological characteristics, yet mechanistic links have remained elusive. T1D results from autoimmune destruction of pancreatic beta cells, whereas beta cell failure in T2D is delayed and progressive. Here we find a new genetic component of diabetes susceptibility in T1D non-obese diabetic (NOD) mice, identifying immune-independent beta cell fragility. Genetic...

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Identifiers

PMID: 26998692
DOI: 10.1038/ng.3531
PMCID: PMC5584070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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