Article
Identification and mapping to chromosome 1 of a susceptibility locus for periinsulitis in non-obese diabetic mice.
Nature - 19 Sept 1991
Garchon H J, Bedossa P, Eloy L, Bach J F
Abstract excerpt
Insulin-dependent diabetes mellitus (IDDM) is a polygenic disease caused by autoimmune destruction of insulin-producing beta cells in the islets of Langerhans. Its onset is preceded by a long and variable period in which lymphoid cells infiltrate the pancreas but first remain outside the islets (...
Topics
- Alleles
- Animals
- Chromosome Mapping
- Crosses, Genetic
- Diabetes Mellitus, Experimental
- Female
- Genetic Linkage
- Genetic Predisposition to Disease
- Genotype
- Haplotypes
- Islets of Langerhans
- Male
- Mice
- Mice, Inbred Strains
- Mice, Mutant Strains
- Pancreatic Diseases
- Salivary Gland Diseases
