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Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis

27 Aug 2025

Abstract excerpt

The loss of insulin secretory function associated with type 1 diabetes (T1D) is attributed to the immune-mediated destruction of beta cells. Yet, at onset of T1D, patients often retain a substantial beta cell mass, and T cell infiltration of pancreatic islets is typically sporadic. Here, we investigate the hypothesis that the remaining beta cells in T1D are dysfunctional, using live pancreas slices from organ...

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PMID: 40875294
DOI: 10.1016/j.celrep.2025.116174

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