Article

Extracellular citrate modulates glutamine metabolism in human macrophages during infection

2026-05-13

Abstract excerpt

Citrate is a central metabolite linking tricarboxylic acid (TCA) cycle activity to energy and lipid metabolism and supports the synthesis of inflammatory mediators, including itaconate, in macrophages. While citrate is primarily generated endogenously, extracellular citrate levels are elevated under pathological conditions such as citrate transporter disorder. Cells import extracellular citrate through SLC13 trans...

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Literature Corpus work: 3f54cb33-4a77-52ee-9e91-2ba955eedb60
DOI: 10.64898/2026.05.13.724857

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