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Article

Tricarboxylic acid cycle metabolites in the control of macrophage activation and effector phenotypes.

Journal of leukocyte biology - 1 Aug 2019

Noe Jordan T, Mitchell Robert A

Abstract excerpt

The tricarboxylic acid (TCA) cycle is a mitochondrial metabolic hub that coordinates the metabolism of carbohydrates, proteins, and fats into carbon dioxide and ATP. At specific points in the cycle, the diversion, import, or export of TCA metabolites allows for the dynamic regulation of a variety of tissue and/or cell-specific phenotypic processes. Recent studies have identified that a number of TCA metabolites...

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PMID: 30768807
DOI: 10.1002/JLB.3RU1218-496R

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