Article
A past and present overview of macrophage metabolism and functional outcomes.
Clinical science (London, England : 1979) - 15 Jun 2017
Curi Rui, de Siqueira Mendes Renata, de Campos Crispin Luiz Aurélio, Norata Giuseppe Danilo, Sampaio Sandra Coccuzzo, Newsholme Philip
Abstract excerpt
In 1986 and 1987, Philip Newsholme et al. reported macrophages utilize glutamine, as well as glucose, at high rates. These authors measured key enzyme activities and consumption and production levels of metabolites in incubated or cultured macrophages isolated from the mouse or rat intraperitoneal cavity. Metabolic pathways essential for macrophage function were then determined. Macrophages utilize glucose to...
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