Article

A novel cell indirect calorimetry method unveils the metabolic fluxomic signatures of human monocyte derived M(LPS+INF-γ) and M(IL-4) macrophages

2025-10-22

Abstract excerpt

Macrophages (MΦ) display distinct immunometabolic phenotypes upon polarization. While transcriptomic analyses have suggested divergent metabolic programs in human M(LPS+INF-γ) and M(IL-4) MΦ, a comprehensive assessment of their metabolic fluxes is lacking. <h4>Aim: </h4> of this study is to 1. develop and validate a novel indirect microcalorimetry method for quantifying cellular metabolic fluxes, and 2. exploit it...

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Literature Corpus work: f00d68bf-7200-5396-95d4-3658013ef4b1
DOI: 10.1101/2025.10.21.681401

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