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Advances into Understanding the Vital Role of the Mitochondrial Citrate Carrier (CIC) in Metabolic Diseases.

Pharmacological research - 1 Nov 2020

Peng Ruyi, Zhang Meng, Wang Haizhou, Lin Jun, Wang Hongling, Wang Fan, Liu Lan, Zhao Qiu, Liu Jing

Abstract excerpt

The mitochondrial citrate carrier (CIC) is a nuclear-encoded protein located in the inner mitochondrial membrane. By mediating efflux of citrate from the mitochondria to the cytosol, CIC links mitochondrial central carbon metabolism and cytosolic lipogenesis together. Abnormal activity or expression of CIC was found in cancers, developmental disorders and many other diseases. Recently, the specific inhibitors of...

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Identifiers

PMID: 32814170
DOI: 10.1016/j.phrs.2020.105132

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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