Article
Myeloid ATP Citrate Lyase Regulates Macrophage Inflammatory Responses In Vitro Without Altering Inflammatory Disease Outcomes.
Frontiers in immunology - 1 Jan 2021
Verberk Sanne G S, van der Zande Hendrik J P, Baardman Jeroen, de Goede Kyra E, Harber Karl J, Keuning Eelco D, Lambooij Joost M, Otto Frank, Zawistowska-Deniziak Anna, de Vries Helga E, de Winther Menno P J, Guigas Bruno, Van den Bossche Jan
Abstract excerpt
Macrophages are highly plastic, key regulators of inflammation. Deregulation of macrophage activation can lead to excessive inflammation as seen in inflammatory disorders like atherosclerosis, obesity, multiple sclerosis and sepsis. Targeting intracellular metabolism is considered as an approach to reshape deranged macrophage activation and to dampen the progression of inflammatory disorders. ATP citrate lyase...
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