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Article

Citrate serves as a signal molecule to modulate carbon metabolism and iron homeostasis in Staphylococcus aureus

30 Jul 2024

Abstract excerpt

Pathogenic bacteria's metabolic adaptation for survival and proliferation within hosts is a crucial aspect of bacterial pathogenesis. Here, we demonstrate that citrate, the first intermediate of the tricarboxylic acid (TCA) cycle, plays a key role as a regulator of gene expression in Staphylococcus aureus. We show that citrate activates the transcriptional regulator CcpE and thus modulates the expression of...

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PMID: 39078849
DOI: 10.1371/journal.ppat.1012425

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