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Article

The citrate transporters SLC13A5 and SLC25A1 elicit different metabolic responses and phenotypes in the mouse.

Communications biology - 9 Sept 2023

Fernandez-Fuente Gonzalo, Overmyer Katherine A, Lawton Alexis J, Kasza Ildiko, Shapiro Samantha L, Gallego-Muñoz Patricia, Coon Joshua J, Denu John M, Alexander Caroline M, Puglielli Luigi

Abstract excerpt

Cytosolic citrate is imported from the mitochondria by SLC25A1, and from the extracellular milieu by SLC13A5. In the cytosol, citrate is used by ACLY to generate acetyl-CoA, which can then be exported to the endoplasmic reticulum (ER) by SLC33A1. Here, we report the generation of mice with systemic overexpression (sTg) of SLC25A1 or SLC13A5. Both animals displayed increased cytosolic levels of citrate and...

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Identifiers

PMID: 37689798
DOI: 10.1038/s42003-023-05311-1
PMCID: PMC10492862

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