Article

Uncoupling of DNA replication and centrosome duplication cycles is a primary cause of haploid instability in mammalian somatic cells

2020-05-30

Abstract excerpt

Mammalian haploid somatic cells are unstable and prone to diploidize, but the cause of haploid instability remains largely unknown. Previously, we found that mammalian haploid somatic cells suffer chronic centrosome loss stemming from the uncoupling of DNA replication and centrosome duplication cycles. However, the lack of methodology to restore the coupling between DNA replication and centrosome duplication has p...

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Literature Corpus work: c7e9acec-b8a1-5492-84a7-d029755af7f2
DOI: 10.1101/2020.05.30.124826

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