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Article

Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells.

1 Jan 2006

Abstract excerpt

In eukaryotic cells, replication of genomic DNA initiates from multiple replication origins distributed on multiple chromosomes. To ensure that each origin is activated precisely only once during each S phase, a system has evolved which features periodic assembly and disassembly of essential pre-replication complexes (pre-RCs) at replication origins. The pre-RC assembly reaction involves the loading of a...

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PMID: 17042960
DOI: 10.1186/1747-1028-1-22

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Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells.PMID 17042960Read ↗

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