Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Depletion of licensing inhibitor geminin causes centrosome overduplication and mitotic defects.

EMBO reports - 1 Nov 2005

Tachibana Kiku-e K, Gonzalez Michael A, Guarguaglini Giulia, Nigg Erich A, Laskey Ronald A

Abstract excerpt

Metazoans limit origin firing to once per cell cycle by oscillations in cyclin-dependent kinases and the replication licensing inhibitor geminin. Geminin inhibits pre-replication complex assembly by preventing Cdt1 from recruiting the minichromosome maintenance proteins to chromatin. Geminin depletion results in genomic over-replication in Drosophila and human cell lines. Here, we show that loss of geminin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caffeine
Share to Centrosome
Share to Chromosome Segregation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin A

Share to HCT116 Cells

Share to Mitosis

Share to Ploidies

Share to Spindle Apparatus

Source

Open in PubMed Open full text

Identifiers

PMID: 16179947
DOI: 10.1038/sj.embor.7400527
PMCID: PMC1371027

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Depletion of licensing inhibitor geminin causes centrosome overduplication and mitotic defects.PMID 16179947Read ↗

Loss of Geminin induces rereplication in the presence of functional p53Semantic proximity Read ↗

Mitosis without DNA replication in mammalian somatic cellsSemantic proximity Read ↗

Cell cycle-dependent subcellular translocation of the human DNA licensing inhibitor geminin.Semantic proximity Read ↗

Repression of nascent strand elongation by deregulated Cdt1 during DNA replication in Xenopus egg extracts.Semantic proximity Read ↗

Geminin prevents rereplication during xenopus development.Semantic proximity Read ↗

Cdt1 and Cdc6 are destabilized by rereplication-induced DNA damage.Semantic proximity Read ↗

Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells.Semantic proximity Read ↗

Levels of the origin-binding protein Double parked and its inhibitor Geminin increase in response to replication stress.Semantic proximity Read ↗

Selective Killing of Cancer Cells by Suppression of Geminin ActivitySemantic proximity Read ↗

Rereplication by Depletion of Geminin Is Seen Regardless of p53 Status and Activates a G<sub>2</sub>/M CheckpointSemantic proximity Read ↗

SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition.Semantic proximity Read ↗

Geminin is essential for the development of preimplantation mouse embryosSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.