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Article

Loss of Geminin induces rereplication in the presence of functional p53

24 May 2004

Abstract excerpt

Strict regulation of DNA replication is essential to ensure proper duplication and segregation of chromosomes during the cell cycle, as its deregulation can lead to genomic instability and cancer. Thus, eukaryotic organisms have evolved multiple mechanisms to restrict DNA replication to once per cell cycle. Here, we show that inactivation of Geminin, an inhibitor of origin licensing, leads to rereplication in...

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Identifiers

PMID: 15159417
DOI: 10.1083/jcb.200403106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Loss of Geminin induces rereplication in the presence of functional p53PMID 15159417Read ↗

Rereplication by Depletion of Geminin Is Seen Regardless of p53 Status and Activates a G<sub>2</sub>/M CheckpointSemantic proximity Read ↗

Cdt1 and Cdc6 are destabilized by rereplication-induced DNA damage.Semantic proximity Read ↗

Depletion of licensing inhibitor geminin causes centrosome overduplication and mitotic defects.Semantic proximity Read ↗

Geminin prevents rereplication during xenopus development.Semantic proximity Read ↗

ATR Pathway Is the Primary Pathway for Activating G2/M Checkpoint Induction After Re-replicationSemantic proximity Read ↗

Selective Killing of Cancer Cells by Suppression of Geminin ActivitySemantic proximity Read ↗

Mitosis without DNA replication in mammalian somatic cellsSemantic proximity Read ↗

Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells.Semantic proximity Read ↗

Human Cdt1 lacking the evolutionarily conserved region that interacts with MCM2-7 is capable of inducing re-replication.Semantic proximity Read ↗

Geminin deficiency causes a Chk1-dependent G2 arrest in Xenopus.Semantic proximity Read ↗

Cell cycle-dependent subcellular translocation of the human DNA licensing inhibitor geminin.Semantic proximity Read ↗

Deregulation of Cdt1 induces chromosomal damage without rereplication and leads to chromosomal instabilitySemantic proximity Read ↗

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