Article

Oligomer-to-Monomer Transition Underlies the Chaperone Function of AAGAB in AP1/AP2 Assembly

2022-03-12

Abstract excerpt

Assembly of protein complexes is facilitated by assembly chaperones. Alpha and gamma adaptin binding protein (AAGAB) is a chaperone governing the assembly of the heterotetrameric adaptor complexes 1 and 2 (AP1 and AP2) involved in clathrin-mediated membrane trafficking. Here, we found that before AP1/2 binding, AAGAB exists as a homotetramer. AAGAB tetramerization is mediated by its C-terminal domain, which is cri...

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Literature Corpus work: 3f203775-0511-5585-bd4d-22b11c64634d
DOI: 10.1101/2022.03.11.483825

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Oligomer-to-Monomer Transition Underlies the Chaperone Function of AAGAB in AP1/AP2 AssemblyDOI 10.1101/2022.03.11.483825Read

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