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Article

The self-association equilibrium of DNAJA2 regulates its interaction with unfolded substrate proteins and with Hsc70.

Nature communications - 5 Sept 2023

Velasco-Carneros Lorea, Cuéllar Jorge, Dublang Leire, Santiago César, Maréchal Jean-Didier, Martín-Benito Jaime, Maestro Moisés, Fernández-Higuero José Ángel, Orozco Natalia, Moro Fernando, Valpuesta José María, Muga Arturo

Abstract excerpt

J-domain proteins tune the specificity of Hsp70s, engaging them in precise functions. Despite their essential role, the structure and function of many J-domain proteins remain largely unknown. We explore human DNAJA2, finding that it reversibly forms highly-ordered, tubular structures that can be dissociated by Hsc70, the constitutively expressed Hsp70 isoform. Cryoelectron microscopy and mutational studies...

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Identifiers

PMID: 37670029
DOI: 10.1038/s41467-023-41150-8
PMCID: PMC10480186

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