Article
Novel binding sites on clathrin and adaptors regulate distinct aspects of coat assembly.
Traffic (Copenhagen, Denmark) - 1 Dec 2006
Knuehl Christine, Chen Chih-Ying, Manalo Venus, Hwang Peter K, Ota Nobuyuki, Brodsky Frances M
Abstract excerpt
Clathrin-coated vesicles (CCVs) sort proteins at the plasma membrane, endosomes and trans Golgi network for multiple membrane traffic pathways. Clathrin recruitment to membranes and its self-assembly into a polyhedral coat depends on adaptor molecules, which interact with membrane-associated vesicle cargo. To determine how adaptors induce clathrin recruitment and assembly, we mapped novel interaction sites...
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