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Article

AAGAB is an assembly chaperone regulating AP1 and AP2 clathrin adaptors

8 Sept 2021

Abstract excerpt

Multimeric cargo adaptors such as AP2 play central roles in intracellular membrane trafficking. We recently discovered that the assembly of the AP2 adaptor complex, a key player in clathrin-mediated endocytosis, is a highly organized process controlled by alpha- and gamma-adaptin-binding protein (AAGAB, also known as p34). In this study, we demonstrate that besides AP2, AAGAB also regulates the assembly of AP1, a...

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PMID: 34494650
DOI: 10.1242/jcs.258587

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