Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A hypomorphic mutation of the gamma-1 adaptin gene (Ap1g1) causes inner ear, retina, thyroid, and testes abnormalities in mice.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jun 2016

Johnson Kenneth R, Gagnon Leona H, Chang Bo

Abstract excerpt

Adaptor protein (AP) complexes function in the intracellular sorting and vesicular transport of membrane proteins. The clathrin-associated AP-1 complex functions at the trans-Golgi network and endosomes, and some forms of this complex are thought to mediate the sorting of proteins in plasma membranes of polarized epithelial cells. A null mutation of the mouse Ap1g1 gene, which encodes the gamma-1 subunit of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Abnormalities, Multiple
Share to Cell Polarity

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Ear, Inner

Share to Retina

Share to Testis

Share to Thyroid Gland

Share to trans-Golgi Network

Source

Open in PubMed Open full text

Identifiers

PMID: 27090238
DOI: 10.1007/s00335-016-9632-0
PMCID: PMC4884160

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A hypomorphic mutation of the gamma-1 adaptin gene (Ap1g1) causes inner ear, retina, thyroid, and testes abnormalities in mice.PMID 27090238Read ↗

Early embryonic death of mice deficient in gamma-adaptin.Semantic proximity Read ↗

De novo and bi-allelic variants in AP1G1 cause neurodevelopmental disorder with developmental delay, intellectual disability, and epilepsy.Semantic proximity Read ↗

Characterization of the AP-1 μ1A and μ1B adaptins in zebrafish (Danio rerio).Semantic proximity Read ↗

AAGAB is an assembly chaperone regulating AP1 and AP2 clathrin adaptorsSemantic proximity Read ↗

Physiological roles of clathrin adaptor AP complexes: lessons from mutant animals.Semantic proximity Read ↗

Genetic analyses of adaptin function from yeast to mammals.Semantic proximity Read ↗

Disruption of AP1S1, causing a novel neurocutaneous syndrome, perturbs development of the skin and spinal cord.Semantic proximity Read ↗

Impact of genetic background on neonatal lethality of Gga2 gene-trap mice.Semantic proximity Read ↗

Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain.Semantic proximity Read ↗

A novel subtype of AP-1-binding motif within the palmitoylated trans-Golgi network/endosomal accessory protein Gadkin/gamma-BAR.Semantic proximity Read ↗

AP1S1 missense mutations cause a congenital enteropathy via an epithelial barrier defectSemantic proximity Read ↗

Loss of the Atp2c1 secretory pathway Ca(2+)-ATPase (SPCA1) in mice causes Golgi stress, apoptosis, and midgestational death in homozygous embryos and squamous cell tumors in adult heterozygotes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.