Article
A hypomorphic mutation of the gamma-1 adaptin gene (Ap1g1) causes inner ear, retina, thyroid, and testes abnormalities in mice.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jun 2016
Johnson Kenneth R, Gagnon Leona H, Chang Bo
Abstract excerpt
Adaptor protein (AP) complexes function in the intracellular sorting and vesicular transport of membrane proteins. The clathrin-associated AP-1 complex functions at the trans-Golgi network and endosomes, and some forms of this complex are thought to mediate the sorting of proteins in plasma membranes of polarized epithelial cells. A null mutation of the mouse Ap1g1 gene, which encodes the gamma-1 subunit of the...
Topics
- Abnormalities, Multiple
- Adaptor Protein Complex 1
- Adaptor Protein Complex gamma Subunits
- Animals
- Cell Polarity
- Disease Models, Animal
- Ear, Inner
- Humans
- Male
- Mice
- Mutation
- Retina
- Testis
- Thyroid Gland
- trans-Golgi Network