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Article

VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease

26 Aug 2016

Abstract excerpt

Mutant Huntingtin (mtHtt) causes neurodegeneration in Huntington's disease (HD) by evoking defects in the mitochondria, but the underlying mechanisms remains elusive. Our proteomic analysis identifies valosin-containing protein (VCP) as an mtHtt-binding protein on the mitochondria. Here we show that VCP is selectively translocated to the mitochondria, where it is bound to mtHtt in various HD models....

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PMID: 27561680
DOI: 10.1038/ncomms12646

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