Article

The RNA helicase eIF4A as a novel target in insect cells to combat arboviral infections

2025-10-25

Abstract excerpt

Arboviruses transmitted by mosquitoes cause major global health burdens, yet few vaccines or antivirals exist. Targeting host factors required for viral replication offers a promising approach. The DEAD-box RNA helicase eIF4A, a core component of the translation initiation complex eIF4F, unwinds structured 5′ UTRs and is critical for many viral RNAs. We tested whether the natural products rocaglates and pateamines...

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Literature Corpus work: 3f1dc796-cb31-537e-87b0-9e3152f1a983
DOI: 10.1101/2025.10.22.683850

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