Article

Broad-spectrum antiviral activity of the synthetic rocaglate zotatifin against multiple viruses

2025-11-18

Abstract excerpt

Viruses pose a significant threat to global public health, yet therapeutic options are limited. Zotatifin, a synthetic rocaglate, targets eukaryotic initiation factor 4A (eIF4A), thereby inhibiting viral protein synthesis and triggering an interferon response. Whether zotatifin exhibits broad-spectrum antiviral activity is unknown. Here we evaluated zotatifin’s cytotoxicity using the MTT method and its antiviral a...

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Literature Corpus work: ff47d6e9-1f9f-5574-9e6d-625219efe1b1
DOI: 10.1101/2025.11.18.689102

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