Article

Integrated phenotypic screening and chemical proteomics identifies ETF1 ligands that modulate viral translation and replication

2025-08-28

Abstract excerpt

<h4>ABSTRACT</h4> Emerging and re-emerging viruses pose a significant threat to global health. Although direct-acting antivirals have shown success, their efficacy is limited by the rapid emergence of drug-resistant viral variants. Hence, there is an urgent need for additional broad spectrum antiviral therapeutic strategies. Here, we identify by phenotypic screening a set of stereochemically defined photoreactive...

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Literature Corpus work: 01890089-0f3d-5389-82d7-03bffd4fcb3f
DOI: 10.1101/2025.08.27.672717

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