Article

The RdRp Thumb-1 Pocket is a Conserved Target for Broad-Spectrum Antiviral Development

2024-04-03

Abstract excerpt

<h4>ABSTRACT</h4> Single-stranded RNA (ssRNA) viruses cause human diseases ranging from mild colds to deadly pandemics. Broad-spectrum non-nucleoside antivirals have been characterized as impossible to develop because allosteric binding sites are poorly conserved. The Thumb-1 allosteric site identified in HCV’s RNA-dependent RNA polymerase (RdRp) governs an essential conformational change in the Λ1-loop required...

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Literature Corpus work: 7928c3ef-4898-5c92-bb9d-b5a123bf379b
DOI: 10.1101/2024.03.29.587401

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