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<i>In silico</i> , biochemical, and <i>in vitro</i> analysis of silvestrol binding to the DEAD box RNA helicase eIF4A reveals broad anti-pathogen potential of rocaglates across the eukaryotic tree of life

2022-09-10

Abstract excerpt

Selective inhibition of eukaryotic initiation factor 4A (eIF4A), an RNA helicase, has been proposed as a strategy to fight pathogens. Plant-derived rocaglates exhibit some of the highest specificities among eIF4A inhibitors. Sensitivity to rocaglates is determined by key amino acid (aa) residues mediating reversible clamping of the eIF4A:RNA complex. To date, no comprehensive assessment of eIF4A sensitivity to roc...

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Literature Corpus work
261e252b-b1bf-576b-9a25-feaba3bff47c
DOI
10.1101/2022.09.09.507249
Open publication

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<i>In silico</i> , biochemical, and <i>in vitro</i> analysis of silvestrol binding to the DEAD box RNA helicase eIF4A reveals broad anti-pathogen potential of rocaglates across the eukaryotic tree of lifeDOI 10.1101/2022.09.09.507249
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