Article

Identification of a series of pyrrolo-pyrimidine based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication

2024-10-29

Abstract excerpt

<h4>ABSTRACT</h4> Coronaviruses (CoVs) can emerge from zoonotic sources and cause severe diseases in humans and animals. All CoVs encode for a macrodomain (Mac1) that binds to and removes ADP-ribose from target proteins. SARS-CoV-2 Mac1 promotes virus replication in the presence of interferon (IFN) and blocks the production of IFN, though the mechanisms by which it mediates these functions remain unknown. Mac1 in...

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Literature Corpus work: b120b5da-f7d8-536e-b20a-f258ccec45ea
DOI: 10.1101/2024.10.28.620664

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