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Article

Selective pharmacological targeting of a DEAD box RNA helicase.

PloS one - 13 Feb 2008

Lindqvist Lisa, Oberer Monika, Reibarkh Mikhail, Cencic Regina, Bordeleau Marie-Eve, Vogt Emily, Marintchev Assen, Tanaka Junichi, Fagotto Francois, Altmann Michael, Wagner Gerhard, Pelletier Jerry

Abstract excerpt

RNA helicases represent a large family of proteins implicated in many biological processes including ribosome biogenesis, splicing, translation and mRNA degradation. However, these proteins have little substrate specificity, making inhibition of selected helicases a challenging problem. The prototypical DEAD box RNA helicase, eIF4A, works in conjunction with other translation factors to prepare mRNA templates for...

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PMID: 18270573
DOI: 10.1371/journal.pone.0001583
PMCID: PMC2216682

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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