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Article

CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A.

Cell reports - 14 Jun 2016

Chu Jennifer, Galicia-Vázquez Gabriela, Cencic Regina, Mills John R, Katigbak Alexandra, Porco John A, Pelletier Jerry

Abstract excerpt

Targeting translation initiation is an emerging anti-neoplastic strategy that capitalizes on de-regulated upstream MAPK and PI3K-mTOR signaling pathways in cancers. A key regulator of translation that controls ribosome recruitment flux is eukaryotic initiation factor (eIF) 4F, a hetero-trimeric complex composed of the cap binding protein eIF4E, the scaffolding protein eIF4G, and the RNA helicase eIF4A. Small...

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Identifiers

PMID: 27239032
DOI: 10.1016/j.celrep.2016.05.005
PMCID: PMC5315212

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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