OptoLoop: An optogenetic tool to probe the functional role of genome organization

Abstract excerpt

<h4>ABSTRACT</h4> The genome folds inside the cell nucleus into hierarchical architectural features, such as chromatin loops and domains. If and how this genome organization influences the regulation of gene expression remains only partially understood. The structure-function relationship of genomes has traditionally been probed by population-wide measurements after mutation of critical DNA elements or by perturb...

Topics

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• Clustered Regularly Interspaced Short Palindromic Repeats
• DNA Repair Mechanisms
• DNA, Single-Stranded
• Epigenetics and DNA Methylation
• Gene Editing
• Genomics and Chromatin Dynamics
• Shelterin Complex
• Telomeres, Telomerase, and Senescence

Identifiers and source

Literature Corpus work

3f1d8f62-0184-5e5e-9df5-38415119bee2

DOI

10.1101/2025.11.06.686574