Article

A versatile system to introduce clusters of genomic double-strand breaks in large cell populations

2020-04-28

Abstract excerpt

<h4>ABSTRACT</h4> In vitro assays for clustered DNA lesions will facilitate the analysis of the mechanisms underlying complex genome rearrangements such as chromothripsis, including the recruitment of repair factors to sites of DNA double-strand breaks. We present a novel method generating localized DNA double-strand breaks using UV-irradiation with photomasks. The size of the damage foci and the spacing between...

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Literature Corpus work: 02c1ff54-8fea-5445-a38e-064ec38cd9c3
DOI: 10.1101/2020.04.27.064105

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