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Article

A sensitive red/far-red photoswitch for controllable gene therapy in mouse models of metabolic diseases

2024-10-02

Abstract excerpt

Red light optogenetic systems are in high demand for the precise control of gene expression for gene- and cell-based therapies. Here, we report a red /far-red light-inducible p hotoswitch (REDLIP) system based on the chimeric photosensory protein FnBphP (Fn-REDLIP) or PnBphP (Pn-REDLIP) and their interaction partner LDB3, which enables efficient dynamic regulation of gene expression with a timescale of seconds w...

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Literature Corpus work
0883da4e-1069-5f14-a97b-09aa3ea0d8dc
DOI
10.1101/2024.09.30.615971
Open publication

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A sensitive red/far-red photoswitch for controllable gene therapy in mouse models of metabolic diseasesDOI 10.1101/2024.09.30.615971
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