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Article

Single-Molecule Imaging of Telomerase RNA Reveals a Recruitment-Retention Model for Telomere Elongation.

Molecular cell - 2 Jul 2020

Laprade Hadrien, Querido Emmanuelle, Smith Michael Joseph, Guérit David, Crimmins Hannah, Conomos Dimitri, Pourret Emilie, Chartrand Pascal, Sfeir Agnel

Abstract excerpt

Extension of telomeres is a critical step in the immortalization of cancer cells. This complex reaction requires proper spatiotemporal coordination of telomerase and telomeres and remains poorly understood at the cellular level. To understand how cancer cells execute this process, we combine CRISPR genome editing and MS2 RNA tagging to image single molecules of telomerase RNA (hTR). Real-time dynamics and...

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Source

Identifiers

PMID: 32497497
DOI: 10.1016/j.molcel.2020.05.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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