Article

Optogenetic manipulation of YAP cellular localisation and function

2021-03-19

Abstract excerpt

YAP, an effector of the Hippo signalling pathway, promotes organ growth and regeneration. Prolonged YAP activation results in uncontrolled proliferation and cancer. Therefore, exogenous regulation of YAP activity has potential translational applications. We present a versatile optogenetic construct (optoYAP) for manipulating YAP localisation, and consequently its activity and function. We attached a LOV2 domain th...

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Literature Corpus work: a2615be8-8013-5bb7-befc-e2c81f1a8ed5
DOI: 10.1101/2021.03.19.436118

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