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Modulating glial genes involved in synaptic function mitigates pathogenesis and behavioral deficits in a <i>Drosophila</i> model of Huntington’s Disease

2020-11-04

Abstract excerpt

Most research on neurodegenerative diseases has focused on neurons, yet glia help form and maintain the synapses whose loss is so prominent in these conditions. To investigate the contributions of glia to Huntington’s disease (HD), we studied transcriptomic changes in HD human, HD mice, and Drosophila expressing human mutant Huntingtin (m HTT ) in either glia, neurons or both. A large portion of conserved genes...

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Identifiers and source

Literature Corpus work
3f1337cf-3bf2-5e54-90e3-52a87f2f84a4
DOI
10.1101/2020.11.03.367326
Open publication

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Modulating glial genes involved in synaptic function mitigates pathogenesis and behavioral deficits in a <i>Drosophila</i> model of Huntington’s DiseaseDOI 10.1101/2020.11.03.367326
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